Novavax: side effects of the new vaccine – that says the package insert

  • fromChristina Rosenberger


Nuvaxovid – A novel vaccine is expected to be approved in Europe soon. How high its effectiveness is estimated and which side effects are known – an overview:

The corona pandemic is coming to a head again. The numbers are not only skyrocketing in Baden-Württemberg. Today the Robert Koch Institute recorded the sad record of over 65,000 new infections within 24 hours (as of November 18) and the intensive care units are filling up again. But what can be done to finally ban the virus from society again?

The first place among the corona measures that the federal government is pushing is still the vaccination campaign. Politicians such as Baden-Württemberg’s Prime Minister Winfried Kretschmann (Greens) have even called for mandatory vaccinations for certain professions. But many Germans are still hesitant to get vaccinated against Corona. The lack of trust in the previous vaccines could also play a major role in some cases.

Corona vaccine from Novavax: These side effects of the dead vaccine are known so far

That is why experts are now again placing hope in a new vaccine. The Novavax company has launched a vaccine called “Nuvaxovid” or “NVX-CoV2373”. This works very differently than the previous ones. Because Novavax is neither an mRNA nor a vector vaccine. Nuvaxovid is according to the Paul Ehrlich Institute (PEI) a protein-based vaccine. It consists of virus-like particles that contain the spike protein from Covid-19 and is called the “dead vaccine”.


Inactivated vaccines that only contain killed pathogens or their components are called inactivated vaccines. These can no longer multiply. The killed pathogens are recognized as foreign by the body. This stimulates the body’s own defense system and forms antibodies. The disease itself does not break out.

But even before the new type of vaccine even comes onto the market, many are of course already asking: What side effects are known to date? After all, the AstraZeneca vector vaccine in particular kept the world busy for its rare but severe side effects that caused cerebral vein thrombosis in vaccinated people. In a few cases, the after-effects of the corona vaccination even resulted in death.

Corona vaccine Nuvaxovid: How effective is the dead vaccine according to the manufacturer Novavax?

For Nuvaxovid, of course, no extensive data on side effects are known yet. In June, the manufacturer Novavax had, according to the Allgäuer newspaper explains that the vaccine showed rather mild “undesirable side effects” in its test phase. We are specifically talking about pressure pain at the injection site, headache and fatigue. However, only about 30,000 people were vaccinated with the inactivated vaccine during the Nuvaxovid study phase.

According to Novavax, the participants from the USA and Mexico had about 90 percent immunity to symptomatic Covid-19 diseases in retrospect. The protection against moderate and severe disease courses was therefore even 100 percent. The inactivated vaccine Nuvaxovid from the US pharmaceutical company Novavax is injected twice.

Corona vaccine Nuvaxovid: When can the dead vaccine come to Germany?

It is not yet clear when Novavax will also be able to offer its vaccine here in Germany. After all, the US vaccine manufacturer submitted an application for approval to the EU Medicines Agency (EMA) in November. There the delivered data is first evaluated and checked. The quality of the vaccine, its effectiveness and safety are the focus of the tests.

According to media reports, Novavax is now expecting approval in Europe in the next few weeks. Then the dead vaccine should actually be the fifth approved vaccine in Germany – and immunizations with this new type of vaccine as an alternative to Biontech, Moderna, AstraZeneca and Johnson & Johnson are possible. The EU secured up to 200 million doses of Nuvaxovid in August.

Rubriklistenbild: © Alastair Grant/AP/dpa

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