Covid: Viennese researchers rely on antibodies in nasal sprays

Covid: Viennese researchers rely on antibodies in nasal sprays
Covid: Viennese researchers rely on antibodies in nasal sprays

“This unexpectedly high effectiveness makes IgA antibodies particularly interesting for new therapeutic approaches, not only for SARS-CoV-2, but also for other pathogens that enter the body via the respiratory tract,” Steinkellner is quoted in a broadcast from the University of Natural Resources and Life Sciences . Because IgA antibodies are “fighters at the forefront”, as it says in the broadcast: They are located on the mucous membranes of the body such as the nasal epithelium and fight intruders practically at the front door.

“The expectations are high”

For the treatment of SARS-CoV-2 infections, the development of special nasal sprays containing such IgA dimers could now represent a new, particularly promising therapeutic approach. The high effectiveness of the IgA molecules in cell systems was initially tested; further studies in animal models are in the planning stage. “The expectations are high,” say the Boku researchers.

Just recently, the Boku team, together with the Medical University of Vienna (Karin Stiasny), succeeded in producing a different type of antibody (IgG3 antibody) with particularly high antiviral activity. This has a 50 times higher SARS-CoV-2 neutralization than previous variants.

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Covid Viennese researchers rely antibodies nasal sprays

 
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