Covid-19: Moderna or Pfizer booster works better in those vaccinated with Johnson & Johnson

Covid-19: Moderna or Pfizer booster works better in those vaccinated with Johnson & Johnson
Covid-19: Moderna or Pfizer booster works better in those vaccinated with Johnson & Johnson

MIXING – People who have received the Covid-19 vaccine from Johnson & Johnson may benefit from a booster dose of a different, messenger RNA vaccine, according to preliminary results from US work released Wednesday.

LCI editorial staff – 2021-10-14T09:10:22.868+02:00

Do we have an interest in “to mix together” vaccines, i.e. to use a different vaccine for the booster dose than for the initial series? This is the question addressed by a long-awaited study in the United States, the preliminary results of which were published on Wednesday. Verdict? People who have received the Covid-19 vaccine from Johnson & Johnson may benefit from receiving a booster dose of a different, messenger RNA vaccine.

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Covid-19: the challenge of vaccination

Antibody levels multiplied by 76

In detail, the study funded by the National Institutes of Health (NIH) was conducted on 458 adults vaccinated with one of the three remedies authorized in the United States (Pfizer, Moderna or Johnson & Johnson), for at least 12 weeks. These three groups were each divided into three new groups, to receive respectively one of the three available vaccines as a booster dose. The nine groups in total therefore consisted of about 50 people each. The researchers then analyzed the antibody levels 15 days after the injection of the booster dose.

In people first vaccinated with Johnson & Johnson, antibody levels increased by 4 times after a booster dose of the same vaccine, by 35 after a booster of Pfizer, and by 76 after a booster of Moderna. And the antibody levels of people first vaccinated with Moderna were each time higher compared to people first vaccinated with Pfizer or Johnson & Johnson, “regardless of the vaccine given for the booster dose,” notes l ‘study.

“No security problem”

Furthermore, “no security problem has been identified” after the administration of the reminders, it is specified.

The study, which has not yet been peer-reviewed, has several limitations, however. First, the booster dosage of Moderna administered was 100 micrograms, which is double what the company is actually envisioning for its booster dose. In addition, the number of participants was reduced, and the immune response could evolve over time, beyond the 15 days observed here.

“It is important not to get carried away by these results”, warned on Twitter Peter Hotez, professor at Baylor College of Medicine. The results of trials on a second booster dose of “J&J” conducted by the company itself over a longer period were “impressive”, he recalled.

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  • 3rd dose: why so few eligible people respond to the booster?
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The NIH study should in any case feed the discussions of a committee of experts from the United States Medicines Agency (FDA), which must study the authorization requests for a booster dose of Moderna and Johnson & Johnson , Thursday and Friday, respectively.

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